autologous anti-ALPP CAR retroviral vector-transduced T cells
A preparation of autologous T lymphocytes that have been transduced with a retroviral vector expressing a chimeric antigen receptor (CAR) targeting alkaline phosphatase, placental type (ALPP; placental alkaline phosphatase; PLAP), with potential immunostimulating and antineoplastic activities. Upon infusion back into the patient, autologous anti-ALPP CAR retroviral vector-transduced T cells target and bind to ALPP-expressing tumor cells, thereby inducing selective toxicity in ALPP-expressing tumor cells. ALPP, mainly expressed in placenta and testis, is overexpressed on certain tumor cell types, such as on a proportion of colorectal cancers while not expressed in any other normal tissues. It plays a key role in tumor cell proliferation.
Synonym: | anti-ALPP CAR-expressing retroviral vector-transduced autologous T cells autologous anti-ALPP CAR T cells autologous anti-ALPP CAR-modified T cells retroviral vector-transduced anti-PLAP CAR autologous T cells |
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