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autologous anti-CD19 CAR T cells GC019F

A preparation of autologous T lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) specific for the tumor-associated antigen (TAA) CD19, with potential immunostimulating and antineoplastic activities. Upon administration, autologous anti-CD19 CAR T cells GC019F target and bind to CD19-expressing tumor cells. This results in a cytotoxic T-lymphocyte (CTL) response against CD19-expressing tumor cells, the release of cytotoxic molecules and the induction of tumor cell lysis. CD19, cluster of differentiation 19, is a B-cell-specific cell surface antigen overexpressed in B-cell lineage tumors. The processing platform used, FasTCAR, shortens the manufacturing time to produce the CAR T cells.
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Synonym:autologous CD19-targeted CAR T cells GC019F
autologous FasTCAR-enabled CD19-targeted CAR T cells GC019F
Code name:GC 019F
GC-019F
GC019F
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