autologous anti-CD4 CAR T cells LB1901

A preparation of autologous T lymphocytes that have been genetically modified and transduced with a lentiviral vector expressing a chimeric antigen receptor (CAR) targeting the tumor-associated antigen (TAA) CD4, with potential immunostimulating and antineoplastic activities. Upon administration, autologous anti-CD4 CAR T cells LB1901 target and bind to CD4-expressing tumor cells, thereby inducing selective toxicity in CD4-expressing tumor cells. CD4 antigen is expressed in CD4-positive T-cell lymphomas.