autologous anti-CDH17 CAR-T cells CHM-2101

A preparation of autologous T lymphocytes transduced with a lentiviral vector expressing a chimeric antigen receptor (CAR) targeting the tumor-associated antigen (TAA) cadherin-17 (CDH17), with potential immunomodulatory and antineoplastic activities. After isolation, transduction, and expansion in culture, the autologous anti-CDH17 CAR-T cells CHM-2101 are reintroduced into the patient and are directed to tumor cells expressing CDH17, which may result in a selective toxicity against, and lysis of CDH17-expressing tumor cells. CDH17, a cell surface adhesion protein, is overexpressed in a variety of cancer cell types.