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autologous anti-Claudin18.2 CAR T cells LB1908

A preparation of autologous T lymphocytes engineered to express a chimeric antigen receptor (CAR) specific for the tumor-associated antigen (TAA) Claudin18.2 (CLDN18.2; A2 isoform of claudin-18), with potential immunostimulating and antineoplastic activities. Upon administration, autologous anti-CLDN18.2 CAR T cells LB1908 specifically recognize and induce selective toxicity in CLDN18.2-expressing tumor cells. CLDN18.2, a tight junction protein, is expressed on a variety of tumor cells, but its expression in healthy tissues is strictly confined to short-lived differentiated epithelial cells of the gastric mucosa.
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Synonym:autologous anti-CLDN18.2 CAR T cells LB1908
autologous Claudin 18.2-targeting CAR-T cells LB1908
Claudin 18.2-targeted autologous chimeric antigen receptor T cells LB1908
Code name:LB 1908
LB-1908
LB1908
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