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autologous anti-CLL-1-CAR T lymphocytes KITE-222

A preparation of autologous T lymphocytes expressing a chimeric antigen receptor (CAR) specific for the tumor-associated antigen (TAA) C-type-lectin-like molecule-1 (CLL-1; CLL1; C-type lectin domain family 12 member A; CLEC12A), with potential immunomodulating and antineoplastic activities. Upon administration, the autologous anti-CLL-1-CAR T lymphocytes KITE-222 specifically target and bind to CLL-1-expressing tumor cells. This induces selective toxicity in tumor cells that express the CLL-1 antigen. CLL-1, a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily, is overexpressed in leukemic stem cells (LSCs) and plays an important role in disease progression and relapse for myeloid malignancies.
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Synonym:autologous anti-CLL-1-CAR T cells KITE-222
autologous anti-CLL-1-CAR-T cells KITE-222
autologous anti-CLL1 CAR T cells KITE-222
Code name:KITE 222
KITE-222
KITE222
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