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autologous anti-FLT3 CAR T cells TAA05

A preparation of autologous T lymphocytes genetically engineered with a chimeric antigen receptor (CAR) specific for the tumor-associated antigen FMS-like tyrosine kinase 3 (FLT3; CD135; STK1; FLK2), with potential immunostimulating and antineoplastic activities. Upon administration, the autologous anti-FLT3 CAR T cells TAA05 target and bind to tumor cells expressing FLT3, which results in the cytotoxic T-lymphocyte (CTL)-mediated cell killing of FLT3-expressing tumor cells. FLT3, a class III receptor tyrosine kinase (RTK), is overexpressed or mutated in most B-lineage neoplasms and in acute myeloid leukemias (AMLs).
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Synonym:autologous anti-FMS-like tyrosine kinase 3 CAR T cells TAA05
autologous FLT3-targeting CAR-T cells TAA05
Code name:TAA 05
TAA-05
TAA05
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