arlocabtagene autoleucel
A preparation of autologous T-lymphocytes engineered to express a chimeric antigen receptor (CAR) specific for the tumor-associated antigen (TAA) human G-protein coupled receptor family C group 5 member D (GPRC5D), with potential immunostimulating and antineoplastic activities. Upon leukapheresis, isolation, transduction, expansion ex vivo, and reintroduction into the patient, arlocabtagene autoleucel specifically recognize and induce selective toxicity in GPRC5D-expressing tumor cells. GPRC5D is overexpressed in certain malignancies, such as multiple myeloma, while minimally expressed in normal, healthy cells. It plays a key role in tumor cell proliferation.
| Synonym: | autologous anti-GPRC5D CAR T cells CC-95266 autologous anti-GPRC5D CAR-T cells CC-95266 GPRC5D-targeted autologous CAR T cells BMS-986393 |
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| Code name: | BMS 986393 BMS-986393 BMS986393 CC 95266 CC-95266 CC95266 |