autologous anti-MAGE-A1 TCR-engineered T cells TSC-204-A0201
A preparation of autologous T lymphocytes that are engineered to express a T-cell receptor (TCR) specific for melanoma-associated antigen A1 (MAGE-A1) presented on human leukocyte antigen (HLA)-A*02:01, with potential immunomodulating and antineoplastic activities. Upon administration, the autologous anti-MAGE-A1 TCR-engineered T cells TSC-204-A0201 specifically recognize and bind to MAGE-A1 expressed on tumor cells. This may lead to cytotoxic T-lymphocyte (CTL)-mediated elimination of tumor cells expressing MAGE-A1. MAGE-A1 is a tumor-associated antigen (TAA) overexpressed by a variety of cancer cell types.
| Synonym: | autologous MAGE-A1-specific HLA-A02:01-restricted TCR-expressing T lymphocytes TSC-204-A0201 MAGE-A1-specific HLA-A02:01-restricted TCR-engineered T cells TSC-204-A0201 MAGE-A1-specific TCR transduced autologous T cells TSC-204-A0201 MAGE-A1-specific TCR-transduced autologous T cells TSC-204-A0201 T-cell receptor engineered T cells TSC-204-A0201 |
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| Code name: | TSC 204-A0201 TSC-204-A0201 TSC204-A0201 |