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autologous anti-mesothelin TCR-expressing T cells FH-TCR TMSLN

A preparation of autologous T lymphocytes that have been genetically engineered to express a T-cell receptor (TCR) specific for the tumor-associated antigen (TAA) human mesothelin (TMSLN), with potential immunomodulating and antineoplastic activities. Upon administration, the autologous anti-mesothelin TCR-expressing T cells FH-TCR TMSLN specifically target and bind to mesothelin-expressing tumor cells. This leads to T-cell activation and T-cell mediated lysis of mesothelin-expressing tumor cells. Mesothelin, a cell surface glycoprotein involved in cell adhesion, is overexpressed in a variety of cancer cell types.
Synonym:autologous mesothelin-specific TCR T cells FH-TCR TMSLN
autologous mesothelin-specific TCR-expressing T cells FH-TCR TMSLN
autologous transgenic T cells expressing mesothelin-specific T-cell receptor FH-TCR TMSLN
Abbreviation:FH-TCR TMSLN
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