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autologous AXL-targeted CAR-T cells CCT301-38

A preparation of genetically modified autologous T lymphocytes transduced with a lentiviral vector to express a chimeric antigen receptor (CAR) targeting the receptor tyrosine kinase (RTK) AXL, with potential immunomodulatory and antineoplastic activities. After isolation, transduction, and expansion in culture, the CCT301-38 cells are reintroduced into the patient and are activated within the tumor microenvironment (TME) using proprietary Conditionally Active Biologic (CAB) technology. Upon activation, CAB antibodies bind to a proprietary T-cell signaling domain, promoting T-cell recognition and killing of AXL-expressing tumor cells. AXL is a RTK and oncogene that is overexpressed in many cancer types and is involved in the stimulation of tumor cell proliferation.
Synonym:autologous anti-AXL CAR-T Cells CCT30138
autologous CAR-T cells targeting AXL CCT301-38
CCT30138 CAR-T cells
Code name:CCT301 38
CCT301-38
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