autologous CAR-engineered regulatory T cells SBT777101

A preparation of autologous T-regulatory cells (Tregs) that have been genetically modified to express a chimeric antigen receptor (CAR) targeting citrullinated proteins, with potential immunmodulating activity. Upon administration, the autologous CAR-engineered regulatory T cells SBT777101 target and bind to citrullinated proteins and may decrease inflammation and promote immunologic homeostasis. Citrullinated proteins are found in inflamed disease-associated tissues in many autoimmune and inflammatory diseases.