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autologous CD30CAR-CD28-CD3zeta-expressing T lymphocytes

A preparation of autologous T lymphocytes (ATL) that have been transduced with the retroviral vector SFG, a Moloney murine leukemia (Mo-MuLV) virus-based vector, encoding a chimeric antigen receptor (CAR) composed of a single chain single-chain variable fragment (scFv) directed against the CD30 antigen (CAR.CD30) and linked, via the spacer human IgG1 immunoglobulin heavy constant region (hinge-CH2CH3 region), to the co-stimulatory domains of CD28 and the zeta chain of the TCR/CD3 complex (CD3-zeta) (CD28zeta), with potential immunostimulating and antineoplastic activities. Upon administration, the autologous CD30CAR-CD28-CD3zeta-expressing T lymphocytes specifically recognize and bind to CD30-expressing tumor cells, resulting in specific T-cell-mediated tumor cell lysis. CD30, a cell surface receptor and a member of the tumor necrosis factor (TNF) receptor superfamily, is transiently expressed on activated lymphocytes and is constitutively expressed in hematologic malignancies.
Synonym:anti-CD30-CAR/CD28z retroviral vector-transduced autologous T cells
ATL-expressing CD30-CAR-CD28zeta
ATLCAR.CD30 cells
ATLCAR.CD30-CD28zeta cells
autologous CAR-CD19-CD28-zeta-transduced T lymphocytes
CAR-CD30-28zeta-specific autologous T cells
SFG.CAR.CD30 autologous T lymphocytes
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