autologous CMV-pp65-flLAMP mRNA-loaded dendritic cell vaccine
A cancer cell vaccine consisting of autologous dendritic cells (DCs) loaded with mRNA encoding the human cytomegalovirus (CMV) matrix protein pp65 (65 kDa lower matrix phosphoprotein; UL83) as a fusion protein with the full-length lysosome-associated membrane protein (flLAMP), with potential immunostimulatory and antineoplastic activities. Upon vaccination, the autologous CMV-pp65-flLAMP mRNA loaded DC vaccine exposes the immune system to the CMV pp65 peptide, which may elicit a cytotoxic T-lymphocyte (CTL) response against CMV pp65-expressing tumor cells. The incorporation of flLAMP may route CMV pp-65 antigens into the lysosomal compartment, resulting in enhanced MHC class II antigen presentation, thereby promoting CD4-positive T-cell responses. The CMV pp65 protein is the primary component of the enveloped subviral particle of CMV and is expressed in certain tumor types.
Synonym: | autologous CMV pp65-LAMP mRNA-loaded DC vaccine autologous CMV-pp65-flLamp DCs autologous flLAMP-pp65 mRNA-pulsed DC vaccine autologous flLAMP-pp65-DC vaccine autologous flLAMP-pp65-DCs autologous pp65-flLAMP DC vaccine autologous pp65-flLAMP DCs |
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