autologous dendritic cell/myeloma fusion vaccine
A therapeutic cancer vaccine consisting of autologous dendritic cells (DCs) fused with patient-derived plasma cell (multiple) myeloma cells with potential immunostimulatory and antineoplastic activities. Upon administration, autologous DC/multiple myeloma fusions stimulate both helper and cytotoxic T-lymphocyte (CTL) responses through the presentation of internalized and newly synthesized tumor associated antigens (TAAs). This may promote cellular and humoral antitumor immune responses in patients with plasma cell myeloma.
Synonym: | autologous DC/multiple myeloma fusions DC/MM fusion vaccine DC/MM fusions DC/multiple myeloma fusions DC/plasma cell myeloma fusion |
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