autologous gamma delta T-cell receptor-expressing T cells TEG002
A preparation of autologous T lymphocytes genetically engineered to express a defined gamma delta T-cell receptor (TCR), with potential immunomodulating and antineoplastic activities. Upon administration of the autologous gamma delta TCR-expressing T cells TEG002, these cells secrete interferon-gamma (IFN-g) and exert direct killing of tumor cells. In addition, these cells activate the immune system to exert a cytotoxic T-lymphocyte (CTL) response against tumor cells. Gamma delta T lymphocytes play a key role in the activation of the immune system and do not require major histocompatibility complex (MHC)-mediated antigen presentation to exert their cytotoxic effect.
Synonym: | autologous gamma delta TCR-expressing T lymphocytes TEG002 |
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Code name: | TEG 002 TEG-002 TEG002 |