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autologous GCC-targeting CAR T cells LCAR-G08

A preparation of autologous T lymphocytes that are genetically engineered, using a lentiviral vector, to express a chimeric antigen receptor (CAR) targeting the enterocyte differentiation antigen guanylyl cyclase C (GUCY2C), with potential immunostimulating and antineoplastic activities. Upon intravenous administration, the autologous GCC-targeting CAR T cells LCAR-G08 are directed to, specifically bind to, activate, proliferate and release cytokines that promote killing of GCC-expressing tumor cells. GCC is overexpressed in various tumor cell types.
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Synonym:autologous anti-GCC-CAR T cells LCAR-G08
autologous GCC-targeting CAR-T cells LCAR-G08
autologous GUCY2C-targeting CAR T cells LCAR-G08
LCAR-G08 Cells
LCAR-G08T
Code name:LCAR G08
LCAR-G08
LCARG08
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