Skip to main content
An official website of the United States government
Government Funding Lapse
Because of a lapse in government funding, the information on this website may not be up to date, transactions submitted via the website may not be processed, and the agency may not be able to respond to inquiries until appropriations are enacted.

The NIH Clinical Center (the research hospital of NIH) is open. For more details about its operating status, please visit cc.nih.gov.

Updates regarding government operating status and resumption of normal operations can be found at opm.gov.

autologous GCC-targeting CAR T cells LCAR-G08

A preparation of autologous T lymphocytes that are genetically engineered, using a lentiviral vector, to express a chimeric antigen receptor (CAR) targeting the enterocyte differentiation antigen guanylyl cyclase C (GUCY2C), with potential immunostimulating and antineoplastic activities. Upon intravenous administration, the autologous GCC-targeting CAR T cells LCAR-G08 are directed to, specifically bind to, activate, proliferate and release cytokines that promote killing of GCC-expressing tumor cells. GCC is overexpressed in various tumor cell types.
Synonym:autologous anti-GCC-CAR T cells LCAR-G08
autologous GCC-targeting CAR-T cells LCAR-G08
autologous GUCY2C-targeting CAR T cells LCAR-G08
LCAR-G08 Cells
LCAR-G08T
Code name:LCAR G08
LCAR-G08
LCARG08
Search NCI's Drug Dictionary