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autologous memory cytokine-enriched natural killer cells

A population of cryopreserved, autologous CD56-positive memory cytokine-enriched natural killer (NK) cells (m-ceNKs), armed with NK cell-activating surface receptors, with potential immunomodulating and antitumor activities. Autologous NK cells are pre-activated ex vivo with a cytokine cocktail, which induces the differentiation of the NK cells into immune-memory m-ceNKs, which possess a unique phenotype. The pretreated NKs exhibit enhanced cytotoxicity and increased interferon-gamma (IFN-g) production. Upon administration, the autologous m-ceNKs may recognize and kill tumor cells.
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Synonym:autologous cytokine-induced memory-like NKs
autologous m-ceNK cells
autologous M-CENKs
autologous memory cytokine-enhanced NK cells
autologous memory cytokine-enriched NK cells
m-ceNK
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