autologous neoantigen-specific T lymphocytes GEN-011
A preparation of autologous, personalized, immunogenic and tumor neoantigen-specific T lymphocytes, with potential immunostimulating and antineoplastic activities. Tumor-specific neoantigen targets of autologous CD4+ and/or CD8+ T cells are identified and T cells that target immunogenic and stimulatory neoantigens are expanded ex vivo. Upon administration, the autologous neoantigen-specific T lymphocytes GEN-011 recognize and bind to tumor cells expressing the targeted neoantigens, resulting in a cytotoxic T-lymphocyte (CTL)-mediated immune response against the patient's tumor cells.
Synonym: | autologous immunogenic neoantigen-specific T cells GEN-011 autologous neoantigen-targeting T cells GEN-011 |
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Code name: | GEN 011 GEN-011 GEN011 |