autologous PRAME-targeting TCR-engineered T cells IMA203
A preparation of autologous T lymphocytes that are genetically modified with a lentiviral vector encoding a T-cell receptor (TCR) specific for the tumor-associated antigen (TAA) preferentially expressed antigen in melanoma (PRAME), with potential antineoplastic activity. Upon intravenous administration back into the patient, the autologous PRAME-targeting TCR-engineered T cells IMA203 specifically recognize and bind to PRAME expressed on cancer cells, which induces a cytotoxic T-lymphocyte (CTL)-mediated immune response against the PRAME-expressing cancer cells. PRAME is overexpressed by a variety of cancer cell types.
Synonym: | ACTengine IMA203 autologous T-cell receptor-engineered T cells IMA203 IMA203 autologous T lymphocytes IMA203 T cells |
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Code name: | IMA 2013 IMA 203 IMA-203 IMA203 |