autologous PRAME-targeting TCR-modified T cells MDG1011
Human autologous T lymphocytes transduced with a retroviral vector encoding a human leukocyte antigen (HLA)-A*02:01-restricted T-cell receptor (TCR) specific for the human tumor-associated antigen (TAA) preferentially expressed antigen in melanoma (PRAME) coupled to the CD3 signaling complex, with potential antineoplastic activity. Upon reintroduction into the patient, the autologous PRAME-targeting TCR-modified T cells MDG1011 target and bind to tumor cells expressing PRAME. This may induce cell death in and halt the growth of PRAME-expressing tumor cells. The TAA PRAME is overexpressed by a variety of cancer cell types.
| Synonym: | autologous anti-PRAME-TCR-expressing T cells MDG1011 autologous PRAME TCR-modified T cells MDG1011 autologous TCR-modified T cells MDG1011 PRAME-TCR gene-modified autologous T cells MDG1011 |
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| Code name: | MDG 1011 MDG-1011 MDG1011 |