Skip to main content
An official website of the United States government
Government Funding Lapse
Because of a lapse in government funding, the information on this website may not be up to date, transactions submitted via the website may not be processed, and the agency may not be able to respond to inquiries until appropriations are enacted.

The NIH Clinical Center (the research hospital of NIH) is open. For more details about its operating status, please visit cc.nih.gov.

Updates regarding government operating status and resumption of normal operations can be found at opm.gov.

autologous Tn-MUC1-specific CAR T lymphocytes

A preparation of autologous T lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) specific for the tumor-associated antigen (TAA) Tn glycoform of mucin-1 (Tn-MUC1; TnMUC1), with potential antineoplastic and immunostimulating activities. Upon re-introduction into the patient, the autologous Tn-MUC1-specific CAR T lymphocytes specifically recognize and induce selective toxicity in TnMUC1-expressing tumor cells. TnMUC1 is overexpressed in certain tumor types.
Check for active clinical trials using this agentView this agent in the NCI Thesaurus
Synonym:anti-TnMUC1-CAR-expressing autologous T lymphocytes
autologous anti-TnMUC1-CAR-expressing T lymphocytes
autologous CART-TnMUC1 cells
autologous Tn-MUC1-specific CAR T cells
autologous TnMUC1-targeted genetically-modified CAR T cells
Search NCI's Drug Dictionary
Please enter up to 30 characters for your search