autologous tolerogenic proinsulin peptide-loaded dendritic cells PIpepTolDC
A vaccine composed of autologous tolerogenic dendritic cells (DCs) loaded with the beta cell protein proinsulin peptide (PIpep), C19-A3, with potential immunosuppressive and immune-regulating activities. Upon intradermal administration, the autologous tolerogenic PIpep-loaded DCs may induce proinsulin-specific regulatory T cells (Tregs). This may suppress the autoimmune destruction of the insulin-producing beta cells, thereby protecting the beta cells.
| Synonym: | autologous tolerogenic DC with proinsulin peptide PIpepTolDC autologous tolerogenic PIpep-loaded dendritic cells PIpepTolDC PIpepTolDC vaccine proinsulin-loaded tolerogenic DCs PIpepTolDC tolerogenic DC vaccine PIpepTolDC |
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| Code name: | PIpepTolDC |