azercabtagene zapreleucel
A preparation of allogeneic, off-the-shelf, T-lymphocytes that have been genetically modified using a proprietary synthetic nuclease-based system to express a chimeric antigen receptor (CAR) targeting the tumor-associated antigen (TAA) CD19 (cluster of differentiation 19) with potential immunostimulating and antineoplastic activities. Upon administration, azercabtagene zapreleucel specifically recognize and kill CD19-expressing tumor cells. CD19 antigen is a B-cell specific cell surface antigen, which is expressed in all B-cell lineage malignancies and normal B-cells.
| Synonym: | allogeneic anti-CD19-CAR T lymphocytes PBCAR0191 allogeneic anti-CD19-CAR T-cells PBCAR0191 allogeneic anti-CD19-CAR T-lymphocytes PBCAR0191 anti-CD19-CAR allogeneic T cells PBCAR0191 anti-CD19-CAR allogeneic T-cells PBCAR0191 |
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| Code name: | PBCAR0191 |