bapotulimab
A mouse/human cross-reactive immunoglobulin G2 (IgG2) monoclonal antibody against the immune checkpoint immunoglobulin-like domain containing receptor 2 (ILDR2; Chromosome 1 Open Reading Frame 32; C1orf32), with potential immune checkpoint inhibitory and antineoplastic activities. Upon administration, bapotulimab targets, binds to and inhibits ILDR2, thereby blocking the immunosuppressive activity of ILDR2. This prevents ILDR2-mediated inhibition of T-cell activities and induces a cytotoxic T-lymphocyte (CTL) response against tumor cells. ILDR2, a type I transmembrane protein belonging to the B7 family of immunomodulatory receptors, negatively regulates T-cell responses.
| Synonym: | anti-ILDR2 inhibitor BAY1905254 anti-ILDR2 monoclonal antibody BAY 1905254 anti-immunoglobulin-like domain containing receptor 2 MoAb BAY1905254 ILDR2 function-blocking antibody BAY1905254 immune checkpoint inhibitor BAY1905254 |
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| Code name: | BAY 1905254 BAY-1905254 BAY1905254 |