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bardoxolone methyl

The methyl ester form of bardoxolone, a synthetic triterpenoid compound with potential antineoplastic and anti-inflammatory activities. Bardoxolone blocks the synthesis of inducible nitric oxide synthase (iNOS) and inducible cyclooxygenase (COX-2), two enzymes involved in inflammation and carcinogenesis. This agent also inhibits the interleukin-1 (IL-1)-induced expression of the pro-inflammatory proteins matrix metalloproteinase-1 (MMP-1) and matrix metalloproteinase-13 (MMP-13) and the expression of Bcl-3; Bcl-3 is an IL-1-responsive gene that preferentially contributes to MMP-1 gene expression.
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Synonym:CDDO methyl ester
CDDO-Me
Code name:RTA 402
Chemical structure:(+)-methyl 2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oate
2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid methyl ester
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