beta-glucan/dexpanthenol/glutamine in mucoadhesive polymer hydrogel

A water soluble, hydrogel-based formulation containing beta-glucan, a polysaccharide isolated from the cell walls of bacteria, plants, and fungi, dexpanthenol, an alcohol derivative of pantothenic acid, the nonessential amino acid glutamine, and preserved water, that can potentially be used to treat mucositis. Upon oral administration of the beta-glucan/dexpanthenol/glutamine in mucoadhesive polymer hydrogel, the mucoadhesive polymer hydrogel interacts with the oral mucosa and promotes contact time between the active ingredients and the mucous membranes in the mouth while also providing moisture and serving as a protective barrier. The additional preserved water may also keep the oral mucosa moisturized. Dexpanthenol is converted to pantothenic acid (vitamin B5) which is required for coenzyme A synthesis as well as for the metabolism of proteins, carbohydrates, and fats. Coenzyme A is involved in fatty acids and sphingolipids synthesis crucial for cell membrane integrity. Dexpanthenol may promote cell proliferation and epithelial remodeling and may provide a protective and healing effect on the oral mucosa. Beta-glucan may stimulate the immune system, may protect against pathogens and may prevent inflammation. Glutamine may also help maintain the integrity of the oral mucosa, prevent cellular damage, and improve cellular recovery. Altogether, this may prevent or reduce radiation/chemotherapy-induced mucositis.