beta-thioguanine deoxyriboside
A thiopurine nucleoside derivative with antineoplastic activity. After conversion to the triphosphate, beta-thioguanine deoxyriboside is incorporated into DNA, resulting in inhibition of DNA replication. This agent is cytotoxic against leukemia cell lines and has demonstrated some activity against leukemia cells in vivo. Beta-thioguanine deoxyriboside demonstrates antineoplastic activity against 6-thioguanine-resistant tumor cells.
| Synonym: | beta thioguanine deoxyriboside |
|---|---|
| Abbreviation: | B-TGDR BTG |
| Chemical structure: | 1,9-dihydro-6H-purine-6-thione, 2-amino-9-(2-deoxy-beta-D-erythro-pentofuranosyl) 2'-deoxythioguanosine 2'-desoxy-6-thioguanosine 6-mercaptoguaninedeoxyriboside 9H-purine-6-thiol, 2-amino-9-(2-deoxy-beta-D-erythro-pentofuranosyl) monohydrate beta-2'-deoxy-6-thioguanosine beta-2'-deoxythioguanosine beta-2'-deoxythiol guanosine thioguanine 9-.beta-D-2'-deoxyriboside thioguanine 9-beta-D-2'-deoxyriboside |
| IND number: | 6874 |