broxuridine
A halogenated thymidine analogue with potential antineoplastic and radiosensitizing activities. Bromodeoxyuridine competes with thymidine for incorporation into DNA, resulting in DNA mutation and the inhibition of cell proliferation. As a radiosensitizer, this agent is associated with the inhibition of repair of radiation-induced DNA double-strand breaks.
| Synonym: | 5-bromodeoxyuridine bromo deoxyuridine bromodeoxyuridine bromouracil deoxyriboside bromouridine |
|---|---|
| US brand name: | Broxine Neomark Neomark-BU |
| Abbreviation: | 5-BrdU BrdU |
| Chemical structure: | 5-bromo-2'-deoxyuridine 5-bromouracil deoxyriboside 5-bromouracil-2-deoxyriboside |