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buffered lidocaine

A solution of 1% lidocaine, an aminoethylamide and a prototypical member of the amide class anesthetics, buffered with 8.4% sodium bicarbonate in a 3:1 ratio, with anesthetic activity. Upon local injection of the buffered lidocaine, lidocaine interacts with voltage-gated Na+ channels in the nerve cell membrane and blocks the transient increase in permeability of excitable membranes to Na+. This prevents the generation and conduction of nerve impulses and produces a reversible loss of sensation. Buffered lidocaine may reduce the pain of the local injection more than unbuffered lidocaine, may reduce the onset time of anesthesia and may increase its duration of action.

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buffered lidocaine

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