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c-raf antisense oligonucleotide ISIS 5132

A synthetic, 20-base antisense oligodeoxynucleotide that hybridizes to c-raf kinase messenger RNA. ISIS 5132 has been shown to specifically suppress Raf-1 expression both in vitro and in vivo. Raf-1 serine/threonine kinase functions as a critical effector of Ras-mediated signal transduction; constitutive activation of this pathway directly contributes to malignant transformation.

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Synonym:	c-RAF antisense ISIS 5132/CGP69846A RAF-IK antisense ODN
Code name:	CGP 69846A CGP69846A ISIS 5132 ISIS-5132
NSC code:	719336

c-raf antisense oligonucleotide ISIS 5132

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