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carbon C 11 YJH08

A radioconjugate composed of YJH08, a synthetic glucocorticoid receptor (GR) agonist, labeled with the positron-emitting isotope carbon C 11, with potential use in imaging via positron emission tomography (PET). Upon intravenous administration of carbon C 11 YJH08, the YJH08 moiety targets and binds to GR on tumor cells. Upon PET imaging, this radioligand may allow for the assessment of GR-expressing tumor cells. This also allows assessment of YJH08's pharmacokinetic profile and affinity of GR-positive tumor cells. The GR, a member of the nuclear receptor superfamily of ligand-dependent transcription factors, is overexpressed in certain tumor types and may be associated with tumor cell proliferation and treatment resistance.
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Synonym:[11C] YJH08
[11C]-5-(4-fluorobenzyl)-10-methoxy-2,2,4-trimethyl-2,5-dihydro-1H-chromeno[3,4-f ]-quinoline
11C YJH08
11C-YJH08
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