Skip to main content
An official website of the United States government
Government Funding Lapse
Because of a lapse in government funding, the information on this website may not be up to date, transactions submitted via the website may not be processed, and the agency may not be able to respond to inquiries until appropriations are enacted.

The NIH Clinical Center (the research hospital of NIH) is open. For more details about its operating status, please visit cc.nih.gov.

Updates regarding government operating status and resumption of normal operations can be found at opm.gov.

carbon C 14 lenvatinib mesylate

A radioconjugate composed of the orally bioavailable mesylate salt form of lenvatinib, a receptor tyrosine kinase (RTK) inhibitor, labeled with the radioisotope carbon C 14, with potential use for evaluating the pharmacokinetic profile of lenvatinib. Upon administration of carbon C14 lenvatinib mesylate, lenvatinib targets and binds strongly to multiple RTKs, including vascular endothelial growth factor receptor 1 (VEGFR1;FLT1), VEGFR2 (KDR), VEGFR3 (FLT4), fibroblast growth factor receptor 1 (FGFR1), FGFR2, FGFR3, and FGFR4, platelet derived growth factor receptor alpha (PDGFRa), KIT, and RET. This inhibits growth of tumor cells that overexpress these RTKs. Labeling of lenvatinib with the radioactive tracer carbon C 14 permits the evaluation of lenvatinib's pharmacokinetic profile, including its absorption, distribution, metabolism, and excretion (ADME).
Check for active clinical trials using this agentView this agent in the NCI Thesaurus
Synonym:14C lenvatinib mesylate
14C-lenvatinib mesylate
Abbreviation:14C-E7080
Search NCI's Drug Dictionary
Please enter up to 30 characters for your search