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carmustine

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An antineoplastic nitrosourea. Carmustine alkylates and cross-links DNA during all phases of the cell cycle, resulting in disruption of DNA function, cell cycle arrest, and apoptosis. This agent also carbamoylates proteins, including DNA repair enzymes, resulting in an enhanced cytotoxic effect. Carmustine is highly lipophilic and crosses the blood-brain barrier readily.
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Synonym:bis-chloronitrosourea
bis(chloroethyl) nitrosourea
carmustin
US brand name:BiCNU
Foreign brand name:Becenun
Carmustinum
Nitrourean
Nitrumon
Abbreviation:BCNU
Code name:FDA 0345
SK 27702
SRI 1720
WR-139021
Chemical structure:1,3-bis(2-chloroethyl)-1-nitrosourea
1,3-bis(beta-chloroethyl)-1-nitrosourea
N,N'-bis(2-chloroethyl)-N-nitrosourea
IND number:969
NSC code:409962
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