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CD19-CD34 tagged metabolically programmed CAR T cells

A preparation of a subset of T lymphocytes, that are metabolically enhanced based on selection and purification on CD34 expression and primed to contain T-helper subset 1 and 17 (Th1/17 hybrid cells), that have been genetically modified to express a chimeric antigen receptor (CAR) targeting the tumor-associated antigen (TAA) CD19, with potential immunostimulating and antineoplastic activities. Upon administration, CD19-CD34tagged metabolically programmed CAR T cells target and bind to CD19-expressing tumor cells, thereby inducing selective toxicity in CD19-expressing tumor cells. CD19 is a B-cell specific cell surface antigen expressed in all B-cell lineage malignancies. These T cells may show enhanced persistence and effector function as compared to other, non-metabolically enhanced, anti-CD19 CAR T cells.
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Synonym:anti-CD19 CAR-expressing CD34tagged metabolically programmed T cells
CD19-CD34t metabolically programmed CAR T cells
CD34-selected metabolically fit CD19 CAR T cells
metabolically programmed CD19 CAR-T cells
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