CD3+/CD19+ cell-depleted autologous hematopoietic stem cells

A preparation of autologous hematopoietic stem cells (HSCs) that have been selectively depleted of CD3-positive (CD3+) T cells and CD19-positive (CD19+) B cells, with potential immune reconstituting activity. Upon administration, the CD3+/CD19+ cell-depleted autologous HSCs are used for autologous stem cell transplant (ASCT) and may allow for rapid and sustained engraftment and immune reconstitution without the autoreactive CD3+ T cells and CD19+ B cells. This may alleviate manifestations of autoimmune diseases such as systemic lupus erythematosus (SLE) and systemic sclerosis.