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CD33-specific CAR lentiviral vector-transduced autologous T lymphocytes

Autologous T lymphocytes transduced with a lentiviral vector expressing a chimeric antigen receptor (CAR) specific for the CD33 antigen, with potential immunomodulating and antineoplastic activities. Upon transfusion, CD33-specific CAR lentiviral vector-transduced autologous T lymphocytes target and induce selective toxicity in CD33-expressing tumor cells. CD33 is expressed on normal non-pluripotent hematopoietic stem cells and on myeloid leukemia cells.

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Synonym:	autologous anti-CD33 CAR-T cells autologous anti-CD33 chimeric antigen receptor T cells autologous CD33-CAR-T cells

CD33-specific CAR lentiviral vector-transduced autologous T lymphocytes

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