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CD44v6-specific CAR-T cells

A preparation of genetically modified T lymphocytes transduced with a lentiviral vector encoding a fourth-generation specific chimeric antigen receptor (4SCAR) specific for CD44 variant domain 6 (CD44v6), with potential immunomodulating and antineoplastic activities. Upon administration, CD44v6-specific CAR T cells specifically recognize and kill CD44v6-expressing tumor cells. CD44, a transmembrane glycoprotein and hyaluronic acid receptor, is expressed in healthy tissue and overexpressed in numerous cancer cell types. CD44v6, the isoform containing the variant domain 6 of CD44 gene, plays a key role in tumor cell invasion, proliferation and metastasis.
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Synonym:4SCAR-CD44v6 T cells
4SCAR-CD44v6 T cells
anti-CD44v6 CAR T cells
CD44v6 CAR-T cells
CD44v6-specific CAR gene-engineered T cells
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