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CD45RA-depleted donor T lymphocytes

A preparation of donor lymphocytes that have been depleted of CD45RA-positive cells, that can potentially be used for immune reconstitution purposes. CD45RA depletion results in a cellular product that contains a high amount of memory T cells (Tm). Upon infusion of the allogeneic CD45RA-depleted T lymphocytes after a hematopoietic cell transplantation (HCT), these cells provide Tm recovery and are able to prevent viral infections. The depletion of the CD45RA-positive cells reduces the risk of graft-versus-host disease (GvHD) upon infusion. CD45RA is expressed on naive T cells, whereas Tm cells are CD45RA-negative. Naive T-cells have the potential to induce GvHD.
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Synonym:CD45RA-depleted allogeneic T cells
CD45RA-depleted allogeneic T lymphocytes
CD45RA-depleted donor T cells
donor CD45RA-depleted (memory) T cells
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