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CD8-depleted non-engrafting HLA-mismatched unrelated donor lymphocytes

A preparation of allogeneic lymphocytes from an HLA-mismatched donor that have been selectively depleted of CD8+ T cells, with potential T-cell reconstitution purposes. Upon infusion, the donor-derived CD8+-depleted lymphocytes may increase the levels of CD4+ T cells (Teffs) and promote T-cell reconstitution. The infusion of donor lymphocytes depleted of CD8 T cells may reduce the risk of inducing graft-versus-host disease (GVHD) compared to the infusion of non-CD8-depleted T cells.

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CD8-depleted non-engrafting HLA-mismatched unrelated donor lymphocytes

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