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cediranib maleate

The maleate salt of an indole ether quinazoline derivative with antineoplastic activities. Competing with adenosine triphosphate, cediranib binds to and inhibits all three vascular endothelial growth factor receptor (VEGFR-1,-2,-3) tyrosine kinases, thereby blocking VEGF-signaling, angiogenesis, and tumor cell growth.
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Synonym:AZD2171 maleate
US brand name:Recentin
Foreign brand name:Recentin
Code name:AZD2171
Chemical structure:4-[(4-fluoro-2-methyl-1H-indol-5-yl)oxy]-6-methoxy-7-[3-(pyrrolidin-1- yl)propoxy]quinazoline (2Z)-but-2-enedioate
quinazoline, 4-[(4-fluoro-2-methyl-1H-indol-5-yl)oxy]-6-methoxy-7-[3-(1- pyrrolidinyl)propoxy]-, (2Z)-2-butenedioate (1:1)
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