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CENP-E inhibitor GSK-923295A

A small-molecule inhibitor of the mitotic kinesin centromere-associated protein E (CENP-E), with potential antineoplastic activity. Upon administration, GSK-923295A binds to and inhibits CENP-E, thereby preventing cell division, inducing cell cycle arrest, and ultimately leading to an inhibition of cell proliferation. CENP-E, a kinetochore-associated mitotic kinesin, plays an essential role in chromosome movement during mitosis and regulates cell-cycle transition from metaphase to anaphase.
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Synonym:centromere-associated protein E inhibitor GSK-923295
Code name:GSK 923295
GSK 923295A
GSK-923295
GSK-923295A
GSK923295
GSK923295A
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