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clodronate disodium

The disodium salt of a nitrogen-free bisphosphonate analog of naturally occurring pyrophosphate. Clodronate binds to calcium and inhibits osteoclastic bone resorption and hydroxyapatite crystal formation and dissolution, resulting in a reduction of bone turnover. This agent may control malignancy-associated hypercalcemia, inhibit osteolytic bone metastasis and decrease pain.

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Synonym:	clodronate clodronic acid disodium salt dichloromethylene diphosphonate
Foreign brand name:	Bonefos Clasteon Difosfonal Loron Mebonat Ossiten
Code name:	CL2MDP

clodronate disodium

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