NCI Drug Dictionary

The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials.

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clodronate disodium
The disodium salt of a nitrogen-free bisphosphonate analog of naturally occurring pyrophosphate. Clodronate binds to calcium and inhibits osteoclastic bone resorption and hydroxyapatite crystal formation and dissolution, resulting in a reduction of bone turnover. This agent may control malignancy-associated hypercalcemia, inhibit osteolytic bone metastasis and decrease pain. Check for active clinical trials using this agent. (NCI Thesaurus)

Synonym:clodronic acid, disodium salt
disodium dichloromethylene diphosphonate
Foreign brand name:Bonefos
Clasteon
Difosfonal
Loron
Mebonat
Ossiten
Code name:CL2MDP