copper Cu 64 LNTH-1363S

A radioconjugate composed of LNTH-1363S, a fibroblast activation protein (FAP) binding ligand and inhibitor (FAPi) chelated to the radionuclide copper Cu 64, and an albumin-binding moiety, with potential use as a tracer for FAP-expressing cancer-associated fibroblasts (CAFs) during positron emission tomography/computed tomography (PET/CT). Upon administration of copper Cu 64 LNTH-1363S, the LNTH-1363S moiety selectively targets and binds to FAP-expressing CAFs. Upon binding, FAP-expressing cells can be detected and LNTH-1363S binding can be assessed during PET/CT imaging. FAP, a membrane-bound dipeptidyl peptidase, is overexpressed on CAFs in the tumor microenvironment (TME) and activated fibroblasts in tissues undergoing extracellular matrix remodeling due to chronic inflammation, fibrosis or wound healing. Its expression is low in normal tissues.