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copper Cu 64 NOTA-PSMAi-PEG-Cy5.5-C' dots

An imaging agent composed of silica-based nanoparticles labeled with a near-infrared (NIR) fluorophore, cyanine 5.5 (Cy5.5), and surrounded by polyethylene glycol (PEG) chains attached to a human prostate-specific membrane antigen (PSMA) inhibitor (PSMAi) and labeled with, via the macrocyclic chelating agent 1,4,7-triazacyclononane-N,N',N''-triacetic acid (NOTA), the radioisotope copper Cu 64, with potential tumor-selective diagnostic properties upon positron emission tomography (PET) imaging. Upon administration of the copper Cu 64 NOTA-PSMAi-PEG-Cy5.5-C' dots, the PSMAi moiety selectively targets and binds to PSMA expressed on tumor cells. Upon PET imaging, PSMA-expressing tumor cells can be visualized and assessed. PSMA, a tumor-associated antigen (TAA) and type II transmembrane protein, is expressed on the membrane of prostatic epithelial cells and overexpressed on prostate tumor cells. The nanoparticle formulation may allow for enhanced uptake in PSMA-positive tumors.
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Synonym:(64Cu)-labeled PSMA-targeting -PEG Cy5.5-C' dots
64Cu-NOTA-PSMA-PEG-Cy5.5-C' dot tracer
64Cu-NOTA-PSMA-PEG-Cy5.5-C' dots
64Cu-NOTA-PSMAi-PEG-Cy5.5-C' dots
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