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CXCR2 agonist MGTA-145

An agonist of CXC chemokine receptor type 2 (CXCR2), with potential hematopoietic stem cell (HSC) mobilization activity. Upon administration, CXCR2 agonist MGTA-145 binds to and activates CXCR2. This releases matrix metalloproteinase-9 (MMP-9), resulting in hematopoietic stem cell (HSC) release from bone marrow and HSC movement into the peripheral circulation. The HSCs can be collected for autologous and allogeneic stem cell transplantation.
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Synonym:GRO-beta
GROb
Code name:MGTA 145
MGTA-145
MGTA145
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