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cyclosporine

A natural cyclic polypeptide immunosuppressant isolated from the fungus Beauveria nivea. The exact mechanism of action of cyclosporine is not known but may involve binding to the cellular protein cytophilin, resulting in inhibition of the enzyme calcineurin. This agent appears to specifically and reversibly inhibit immunocompetent lymphocytes in the G0-or G1-phase of the cell cycle. T lymphocytes are preferentially inhibited with T-helper cells as the primary target. Cyclosporine also inhibits lymphokine production and release.
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Synonym:Ciclosporin
cyclosporin
cyclosporin A
cyclosporine modified
US brand name:Gengraf
Neoral
Sandimmune
SangCya
Abbreviation:CsA
CYA
Code name:27-400
OL 27-400
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