cytarabine
View Patient InformationAn antimetabolite analogue of cytidine with a modified sugar moiety (arabinose instead of ribose). Cytarabine is converted to the triphosphate form within the cell and then competes with cytidine for incorporation into DNA. Because the arabinose sugar sterically hinders the rotation of the molecule within DNA, DNA replication ceases, specifically during the S phase of the cell cycle. This agent also inhibits DNA polymerase, resulting in a decrease in DNA replication and repair.
| Synonym: | .beta.-Cytosine arabinoside 1-beta-D-arabinofuranosyl-4-amino-2(1H)pyrimidinone 2(1H)-pyrimidinone, 4-Amino-1-beta-D-arabinofuranosyl- arabinofuranosylcytosine arabinosylcytosine aracytidine beta-cytosine arabinoside cytarabine hydrochloride cytarabinum cytosine arabinoside cytosine arabinosine hydrochloride cytosine-.beta.-arabinoside cytosine-beta-arabinoside tarabine PFS |
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| Foreign brand name: | Alexan ARA-cell Arabine Aracytin Aracytine Cytarbel Cytosar Erpalfa Starasid Udicil |
| Abbreviation: | ARA-C |
| Code name: | CHX-3311 U 19920 U-19920 U-29920A HCl WR-28453 |
| Chemical structure: | 1-.beta.-D-arabinofuranosyl-4-amino-2(1H)pyrimidinone 1-beta-D-arabinofuranosylcytosine 1.beta.-D-arabinofuranosylcytosine 2(1H)-pyrimidinone, 4-amino-1.beta.-D-arabinofuranosyl- 4-amino-1-beta-D-arabinofuranosyl-2(1H)-pyrimidinone |
| IND number: | 1714 |
| NSC code: | 287459 |