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dapsone

A synthetic derivative of diamino-sulfone with anti-inflammatory and anti-bacterial properties. As a structural analog of p-aminobenzoic acid (PABA), dapsone inhibits dihydropteroate synthase (DHPS), an enzyme important in folate synthesis, resulting in a depletion of the folate pool and a reduction in the amount of thymidylate available for DNA synthesis. Although the exact mechanism through which dapsone exerts its anti-inflammatory activity has yet to be fully elucidated, this agent interferes with the activation and oxidative damage of myeloperoxidase in neutrophils and inhibits the integrin-mediated adherence and chemotaxis of neutrophils. Dapsone's anti-inflammatory activities may contribute to the effects seen upon topical administration.
Synonym:croysulfone
diphenasone
dumitone
novophone
sulfona-mae
sulphadione
US brand name:Aczone
Avlosulfon
Disulone
Foreign brand name:Eporal
Undolac
Abbreviation:DADPS
DDS
Code name:1358F
Chemical structure:4,4'-sulfonylbisbenzamine
4,4'-sulfonylbisbenzeneamine
4,4'-sulfonyldianiline
bis(4-aminophenyl)sulfone
NSC code:6091
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